autocrine signaling in cancer

Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine Autocrine signaling was first described 4 decades ago in processes of tumor growth15and was originally thought to be limited to states of disease. It comes from auto-, a Greek

arayo@gifu-pu.ac.jp; Cancer is a disease in which down-regulation of apoptosis often occurs, and this often appears to compromise chemotherapy using anti-cancer drugs.

Cancerous cells secrete a variety of growth signals to themselves, through autocrine signaling, and to nearby tissues. Autocrine TNF Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis Summary A small-molecule mimetic of Smac/Diablo that CiteSeerX - Scientific documents that cite the following paper: Autocrine PDGFR signaling promotes mammary cancer metastasis, Metastasis is a multistep process including Cancer research. Background Aberrant activation of the Wnt/-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Many cytokines upregulated in cancer cells are mediated through autocrine signaling. Diffusive signaling molecules released by the cancer cells themselves sub-sequently bind to cell surface receptors, which triggers a signaling cascade ultimately leading to the up-regulation of cell division. adj. In paracrine signaling, they act on nearby cells. Other articles where autocrine function is discussed: cell: Types of chemical signaling: In the autocrine signaling process, molecules act on the same cells that produce them. Cancerous cells secrete a variety of growth signals to themselves, through autocrine signaling, and to nearby tissues. The abundance of semaphorin 3D (Sema3D) is increased in the tumors of patients with metastatic pancreatic ductal adenocarcinoma (PDA), and antibodies against the protein annexin A2 are present in patient sera. 1 (AG-028262 and sFlt1, respectively), whereas the pericyte-induced autocrine signaling by VEGF-A is only sensitive to intra-cellularly acting inhibitors. Mechanistic studies showed that SHH signaling activated the SHH/GLI1/BCL-2 axis, leading to the inhibition of myeloma cell apoptosis. Three of four pancreatic adenocarcinoma cell lines tested exhibited autocrine Wnt signaling, in that extracellular Wnt ligands were required to initiate downstream Wnt signaling. 2022 Feb 7:canres.1807.2021. Define autocrine. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy. bmp cancer autocrine signaling colorectal therapeutic target figure In addition to polypeptide growth factors such as EGF family members which signal through receptor tyrosine kinases, accumulating evidence supports the autocrine and paracrine involvement of specific neuropeptides with defined physiologic Efforts to model autocrine signaling for drug development have been hampered by conflicting reports of the presence or absence of autocrine signaling in established human prostate Tumorigenesis is a multistep process that requires constitutive cell division, growth, and survival. VEGF, produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma cells. Evidence shows that autocrine VEGF is involved in two major aspects of invasive carcinoma: survival and migration. cells mediates enhances chemoresistant survival cancer lung induced tumor chemotherapy macrophages immunosuppression associated figure Previous Autocrine growth factor signaling could be a likely mechanism behind Allee effects in cancer cell populations. Under hypoxia, the cells are forced to adapt alternative and self-supporting mechanisms. Ovarian cancer (OC) is the most deadly gynaecological malignancy with unmet clinical need for new therapeutic approaches. The ability of cancer cells to produce and to respond to their own growth factors (autocrine secretion) has become a central concept linking oncogene and growth factor research. autocrine synonyms, autocrine pronunciation, autocrine translation, English dictionary definition of autocrine. Patients often experience formation of malignant ascites, fluid formation within the abdominal cavity that contains tumor cells. Interleukin 8 (IL-8) was identified as one of RANKL-induced cytokines and validated for its role in osteoclast formation using inhibitors of the IL-8 cognate receptors CXCR1 and homing subline of the human breast cancer cell line MDA-231, with regard to their impact on specific malignant phenotypes and breast cancer cell signaling, as well as paracrine signaling Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression. Semaphorin signaling directs the migration of developing neurons, as well as new blood vessels. Here, using cell lines and xenograft models, we demonstrate that relaxin The abundance of semaphorin 3D (Sema3D) is increased in the tumors of patients with Thus, autocrine PDGFR signaling plays an essential role during cancer progression, suggesting a novel application of STI571 to therapeutically interfere with metastasis. CiteSeerX - Scientific documents that cite the following paper: Autocrine PDGFR signaling promotes mammary cancer metastasis, Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. Results obtained using BCa-derived cell lines indicate that autocrine signaling via the GAS6/AXL, MST1/MST1R, or CSF1/CSF1R pathways drives cell migration and proliferation, An important downstream signaling pathway of TGF in fibroblasts is transactivation of an autocrine loop of IL11. Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. doi:10.1186/bcr1769 . 2016;7:16311-16324 34.

recently reported that Wnt/-catenin signaling augments self-renewal and inhibits the differentiation of liver CSCs by the expression of the stem cell marker EpCAM 11 . Autocrine IL-6 is implicated as an important activator of oncogenic Stat3 in lung adenocarcinomas and PC . 2022 Feb 07 [Epub ahead of print] The vasoconstrictor response initiated by a1-adrenoceptor activation in arterioles appears to be very complex and also involves autocrine signaling mediated by ATP release through pannexin channels. Colorectal cancer cells undergo apoptosis following the inhibition of autocrine BMP-4 signaling To examine the role of BMP-4 on colorectal cancer tumor growth, shRNA Tamoxifen (TAM) is widely used in the chemotherapy of breast cancer and as a preventive agent against recurrence after surgery. One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors.

which is promoted by activation of the STAT5 signaling pathway. An important downstream signaling pathway of TGF in fibroblasts is transactivation of an autocrine loop of IL11. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to cell signaling by endocrine factors, hormones which travel considerably Autocrine Transforming Growth Factor- Signaling Mediates Smad-independent Motility in Human Cancer Cells* Received for publication, May 13, 2002, and in revised form, October 25, 2002 Published, JBC Papers in Press, November 5, 2002, DOI 10.1074/jbc.M204623200 Nancy Dumont, Andrei V. Bakin, and Carlos L. Arteaga A high-fat diet and obesity are associated with PCa progression and Arayo Haga, Corresponding Correlated expression of two genes at the mRNA level suggests that

Mechanistic studies showed that SHH signaling activated the SHH/GLI1/BCL-2 axis, leading to the inhibition of myeloma cell apoptosis. This is the difference between autocrine and paracrine. Recently, we discovered that ICD is coupled to the. On the contrary, paracrine hormone binds with the receptors on the surfaces of nearby cells and affects the functions of those cells. Previous studies revealed pivotal functions of WNT family members in colorectal cancer, as well as their prognostic values. Recent studies have shown that SHH signaling is abnor-mally activated in neuroblastoma, colorectal cancer, basal cell cancer, medulloblastoma, prostate cancer, ovarian can-cer, pancreatic cancer, and other forms of cancer [10, 13]. "Breast cancer stem cells rely on these signals to maintain themselves, so they remain susceptible to blocking this autocrine signaling. Arayo Haga, Corresponding Author. Documents; Authors; Tables; Documents: Advanced Search Include Citations Authors: Advanced Search Include Citations Tables: Hynes NE (2007) Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Concerning hormones, autocrine is the mode of action of a hormone that binds with the receptors on the same cell surface and affects the cell that produces it. Cancer Res. Moreover, while these signalling pathways may well be antithetical to stemness in pluripotent stem cells, they may cooperate with pluripotency factors in cancer stem cells - a "Breast cancer stem cells rely on these Furthermore, we also demonstrated that autocrine CCL5 signaling plays a pivotal role in CSLC metastasis in vivo. The INSL5-GPCR142 axis can be a potential therapeutic target for NPC treatment. Autocrine growth factor signaling could be a likely mechanism behind Allee effects in can-cer cell populations. Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Tumor development is a complex process that requires cell division, growth, and survival. Autocrine signals include extracellular matrix molecules and various factors that stimulate cell growth. For example, progesterone appears to act in an autocrine manner in Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression. Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. Pancreatic ductal adenocarcinoma (PDAC) harbors a complex tumor microbiome that has been implicated in cancer progression and resistance to chemotherapy. Celecoxib (CXB), a selective COX-2 inhibitor, suppresses VEGF AMF Signal Transduction Pathways of AMF in Human Pancreatic Cancer. the cancer setting. The relaxin peptide is a pleiotropic hormone with reproductive functions in the Relaxin autocrine signaling promotes survival in OC cells. "These autocrine signals are not something breast cancer cells invent anew, but derive instead an activation of normal stem cell programs," says Scheel. Our data suggest that the autocrine TGF-/ZEB/miR-200 signaling axis may be involved in mediating progression of breast cancer. Title:VEGF/VEGFR2 Autocrine Signaling Stimulates Metastasis in Prostate Cancer Cells VOLUME: 3 ISSUE: 4 Author(s):Matthew Migliozzi, Yasuhiro Hida, Meetu Seth, Graham Brown, Joanne Kwan, Silvia Coma, Dipak Panigrahy, Rosalyn M. Adam, Jacqueline Banyard, Akio Shimizu and Diane R. Bielenberg Affiliation:Vascular Biology Program, Boston Childrens Hospital, 300 Longwood Background Sonic hedgehog (SHH) plays critical roles in cell growth and development. Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to initiate signaling. The present investigation was undertaken to examine whether Slfn-3 plays a role in regulating differentiation of FOLFOX In the present study, using immunohistochemistry, we found that AMF was highly expressed in EC tissues compared with Biochem Biophys Res Commun 388: 752756, 2009). Thus, this study identifies the myeloma autocrine Hh signaling pathway as a potential target for the treatment of MM. Further, Yamashita et al. CiteSeerX - Scientific documents that cite the following paper: Hynes NE (2007) Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Online ahead of print.ABSTRACTWnt signaling driven by genomic alterations in Autocrine Search terms: Advanced search options. TGFB signalling in macrophages increases mammary cancer susceptibility potentially through suppression of immune surveillance activities of macrophages. INSL5 promotes tumor progression through an autocrine mechanism involving binding to its receptor GPCR142. Here, we formulate and analyze an individual-based model of cancer, in which cell division rates are increased by the local concentration of an autocrine growth factor produced Aberrant activation of the Wnt/-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Breast Cancer Res 9: R63 Some studies have suggested that SHH signaling activation could contribute to carcinogenesis [1417]. "These autocrine signals are not something breast cancer cells invent anew, but derive instead an activation of normal stem cell programs," says Scheel. The main difference between autocrine and paracrine is that the autocrine factors act on the cells which produce them whereas the paracrine factors act on the cells that are in close proximity to the cells that produce them. Breast Cancer Res 9: R63. Targeting this pathway may improve the efficacy of chemotherapy in MM patients. These autocrine-signaling loops initiate and maintain the differentiation of fibroblasts into myofibroblasts and the concurrent tumor-promoting phenotype. Autocrine signalling is a type of cell communication, that occurs when the cell secretes a substance that is capable of provoking a reaction in itself [1] . Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. Clinical studies have shown elevated serum IL-6 concentrations in cancer patients , including those with PC (10, 11), and serum IL-6 levels correlate with tumor stage, survival, metastasis and cachexia in several malignancies . Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. 92 Autocrine IL11 signaling does not primarily change mRNA levels of profibrotic factors but alters protein levels by activating translational processes and the noncanonical extracellular signalregulated kinase pathway. Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. Oncotarget. The autocrine stimulation is of crucial importance for the growth and survival of tumor cells, and may offer opportunities for treatment of patients by targeting growth factors and their receptors. Hypoxia is a microenvironmental stress in many pathological conditions, including wound healing and tumor invasion. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Here, we formulate and analyze an individual-based model of cancer, in which cell division rates are increased by the local concentration of an autocrine Autocrine stimulation often operates in autocrine loops, a type of interaction, in which a cell produces a mediator, for which it has receptors, that upon activation promotes expression autocrine signaling can result in cancer cells less dependent on survival and growth factors from surrounding tissues 1,2. doi: 10.1158/0008-5472.CAN-21-1807.

Thus, this study identifies the They further show that autocrine Wnt production is a nongenomic driver of canonical and noncanonical Wnt signaling in PC, which can be targeted with Wnt synthesis inhibitors to suppress tumor growth. Tumor cells express SHH, which can promote cell proliferation and epithelial-to Our results suggested that sorafenib might have substantial angiogenesis-independent effects directly through blocking autocrine VEGF signaling on HCC cancer cells. Interleukin 8 (IL-8) was identified as one of RANKL-induced cytokines and validated for its role in osteoclast formation using inhibitors of the IL-8 cognate receptors CXCR1 and CXCR2 or an IL-8 blocking antibody. Autocrine IL-6 Signaling: A Key Event in Tumorigenesis? Anti-cancer drug 3,3'-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis. An example of paracrine signals is the chemical Prostate cancer (PCa) affects an estimated 250,000 men every year and causes 34,000 deaths annually. However, au - tocrine signaling plays a role The bombesin-like peptides, GRP and NMB, were among the first neuropeptides to be implicated as autocrine growth factors in lung cancer cells. Recent clinical investigations uncovered a correlation between high loads of intratumor Fusobacterium nucleatum and decreased patient survival. Transforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. Breast Cancer Research, 9(5). Collectively, these findings indicate that the establishment of the self-sustaining TGF- and SDF-1 autocrine signaling gives rise to tumor-promoting CAF myofibroblasts during tumor progression. In summary, our study demonstrates that pro-LGMN is a novel cancer cell autocrine motility factor, which promotes breast cancer cell migration, invasion and metastasis via Here we show that healthy and cancerous Pharmacological interference with AREG-activated MAPK-signaling overcomes the castration-resistant properties of LY6D + cells with a near complete suppression of organoid formation. Oncogenes confer growth factor autonomy on cells not only by coding directly for autocrine peptide growth factors or their receptors, but also by amplifying the mitogenic Autocrine activity of IL-6 affects hollow lumen formation. Relating to the release of chemical substances from endocrine cells that bind to receptors on the same cell that produces them. 3 min read. Journal Article (Journal Article) INTRODUCTION: The human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase (RTK) oncogene is an attractive therapeutic target for the treatment of HER2-addicted tumors. Semaphorin signaling directs the migration of developing neurons, as well as new blood vessels. In small cell lung cancer (SCLC) We report here a novel autocrine signaling mechanism by which hypoxia Relaxin induces cell growth in several types of cancer, but the role of relaxin in OC is poorly understood. Cancer results from the concerted action of malignant cells interacting with the many cellular and protein components of the tumor stroma. One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. Studies with human small cell lung cancer (SCLC) cells Autocrine signaling loops with positive or negative feedback are an important feature in cancer, where they enable context-dependent cell signaling in the regulation of Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to Paracrine signaling is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce changes in nearby cells, altering the behaviour of those cells. induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, Zhou Y, Xu H, Xu W. et al. Autocrine TNF Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis Sean L. Petersen, Lai Wang, Asligul Yalcin-Chin, Lin Li, Michael Peyton, John Minna , Diffusive signaling molecules released by the cancer cells 92 Autocrine IL11 signaling does not primarily Nevertheless, the prognostic role and mechanisms underlying WNT7b in It has been defined that outstanding characteristics of cancer cells, such as proliferation rate, phenotypic plasticity, and the ability to modify the environment, are highly regulated by autocrine-paracrine mechanisms. Besides the autocrine pathway identified in this study, it has Cancer cells are able to release nano-sized vesicles, called exosomes, which modulate tumor behavior in the surrounding microenvironment. Autocrine and paracrine TGF- signaling regulate XIAP gene expression.We have previously reported that TGF- isoforms increase XIAP protein levels in endometrial carcinoma cells [] and we observed that each TGF- isoform also upregulates XIAP protein content in HeLa cervical carcinoma cells (Figure 2A), indicating that the regulation of XIAP protein levels by TGF

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autocrine signaling in cancer